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KMID : 1059520080520010036
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Journal of the Korean Chemical Society
2008 Volume.52 No. 1 p.36 ~ p.46
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Synthesis, Reaction and Antiviral Activity of 2,4-Diaryl-1,3-selenazoles
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Ali Z. Al-Rubaie
Wasfi A. Al-Masoudi
Lina Z. Yousif
Mohsen Graia
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Abstract
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The cyclization of primary arylselenocarboxylic amides with α-bromoketones afforded a variety of new 2,4-diaryl-1,3-selenazoles. Halogenation of the 2,4-diaryl-1,3-selenazoles with chlorine, bromine and iodine gave the new 1,1-dihalo-2,4-diaryl-1,3-selenazoles in good yields. Antiviral activity of some 1,1-dihalo-2,4-diaryl-1,3-selenazoles has been tested against AIDS virus (HIV-1 and HIV-2). They showed some bioactivity against HIV-1. All compounds were characterized by their elemental analysis, 1H NMR and mass spectroscopic data. The crystal structure of 2-(3,4- dimethoxyphenyl)-4-(4-bromophenyl)-1,3-selenazole displays the molecular configuration.
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KEYWORD
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1,3-Selenazoles, arylselenocarboxamides, α-bromoketones, X-ray, HIV-1,1,3-Selenazoles, arylselenocarboxamides, α-bromoketones, X-ray, HIV-1
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